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Czf1 mutants filament normally under standard filamentation induction conditions, but they are defective in hyphal development in anaerobic conditions [ 41].
Several truncations of this C-terminus have been constructed; the mutants are viable and therefore competent for S phase and the replication function of DDK, but they are defective in response to alkylating damage (Dolan et al., 2010; Fung et al., 2002; Ogino et al., 2001).
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But that is not a sign they are defective — just the opposite.
Any of these appliances can cause serious damage if they are defective or spring a leak.
Their brains can't get off the thought that they are defective in some fundamental, critical way.
"I was arguing that the tickets were invalid because they were defective".
"The bras were seconds, actually — they were defective bras," he said.
Kharms's stories are truly odd, as in: at first you think they're defective.
"They send out the screeners and they're defective; 3,500 defective screeners.
Some used the lists with full knowledge that they were defective.
In this alternative paradigm, viruses with elevated frequencies of CpG and UpA are not intrinsically defective but they are more readily recognised by the cell and prevented from initiating replication.
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