Sentence examples for but the functional importance from inspiring English sources
HBP binds to proteoglycans on endothelial cells, but the functional importance of this binding for increases in permeability has not been investigated before [3, 4].
Other receptors capable of responding to extracellular calcium ions also have been identified, but the functional importance of these interactions remains to be determined.
LMO4 is expressed in the amacrine cell layer of the postnatal day 0 mouse retina [29], but the functional importance of LMO4 in the development of the mammalian retina has not been studied.
Abundant expression of at least two other TG isozymes, TG1 and TG3, in the CNS has been shown (Kim et al. 1999), but the functional importance of this remains to be investigated.
Some differences in glycosylation were observed in XBP-1-deficient cells (McGehee et al, manuscript in preparation), but the functional importance of these altered terminal glycans in BCR signalling has yet to be explored.
29 Furthermore, HAMLET has been shown to activate caspase-3 in tumour cells 30 but the functional importance of this response has been unclear, as caspase inhibition does not prevent the cytotoxic response to HAMLET.
The availability of Rage knockout mice has not only advanced our knowledge on signalling pathways within these pathophysiological conditions, but also on the functional importance of the receptor in processes of cancer.
The similarity of our model to the SatP fold is not only supported by mutagenesis data but also suggests the functional importance of multimeric assembly not revealed by co-evolution or conservation analysis alone.
In the past decade a number of reports have described the incorporation of BM-derived EPCs into tumor vessels in both spontaneous murine tumor models and human patients [6], [7] but the extent of incorporation and the functional importance of these cells is still under intense debate.
Our work does not contribute to the estimate of overall genetic variance explained for SLE, but it does add evidence to the functional importance of the ITGAM locus to SLE susceptibility.
