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Indeed, total O-GlcNAc and protein O-GlcNAcylation are elevated in the diabetic heart [ 4, 39], but the functional implications of this finding are unclear as elevated cardiac O-GlcNAc is implicated in heart failure and cardiac dysfunction [ 39, 40], but also cardioprotection [ 41, 42].
Interestingly, a sumoylation consensus site is also present in MBD4 (MED1), but the functional implications of this remain to be established.
Microtubule (MTs) and actin-myosin arrays interact and cooperate in many mechanochemical modules of cell motility and cell division [1] but the functional implications of such interactions are not well understood.
Expression levels of neurotrophins and Trk receptors are altered in neurodegenerative diseases, but the functional implications are currently unclear.
The intronization of exons has been identified previously in retroposed genes of mammals (Szczesniak et al. 2011), but the functional implications of intronization are not yet known.
The fact that the transcript found in panicle was misspliced to prevent production of active enzyme is intriguing, but the functional implications of the alternative splicing of both OsBgal6 and OsBgal11 remain to be clarified.
Similar(53)
It is not only the presence of drug target, but also the functional implications of blocking the target that are important.
The deciphering of the functional implications of changes in DNA methylation is difficult but of pivotal importance.
Zikherman, J. & Weiss, A. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.
How H3K36 modification is coordinated through the cell cycle and the functional implications for such regulation are currently unknown.
The functional implications of these findings are discussed.
More suggestions(15)
but the functional outcome
but the functional impact
but the functional effect
but the functional consequence
but the contemporary implications
but the full implications
but the functional disabilities
but the functional roles
but the functional SNPs
but the functional antecedents
but the functional characteristics
but the functional groups
but the regulatory implications
but the political implications
but the functional consequences
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