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Until the present time, a total of ∼122 germline variations in POLI gene have been described for human individuals in dbSNP (http://www.ncbi.nlm.nih.gov/projects/SNP), but the functional impacts of these genetic variations have not been biochemically evaluated yet.
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There are indications that some de novo non-synonymous substitutions could be associated with various intellectual disabilities but the functional impact of these mutations is not well understood [ 45].
This technique offers a way of measuring the functional impacts of connections but it also requires the sacrifice of the animals.
The functional impacts from indels are also difficult to predict.
However, the functional impacts and clinical relevance of these genes have not been further investigated.
High-throughput transcriptome studies are producing a fast-growing catalog of splicing variation in human populations, but so far information on the functional impact of such splicing variation is limited, and few if any analogous studies are available for plants.
To check this hypothesis, we further studied the functional impact of all missenses SNPs on RIG-I function.
'Sequence-derived' fGSA regarding the functional impact of not only coding genes, but also non-coding regulators, is necessary.
Similarly, the functional impact of either cognition or brain morphology in relatives remains unknown.
Our goal was to investigate the functional impact of trait-impulsivity in BP.
However, further studies are required to confirm the functional impact of this variant on diabetic nephropathy.
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