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A subset of these SNPs are associated with quantitative expression of nearby genes, but the functional effects of the majority remain unknown.
Also, in peripheral nerves of laminin α2 deficient mice, laminin α1 can be detected [ 53, 54], but the functional effects of this compensatory upregulation are not yet clear.
CGH in principle defines only the chromosomal structural changes, but the functional effects of CNAs can be reflected by altered gene expression.
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In this particular setting, DRF may therefore not sufficiently depict but overestimate the functional effects of renal injury, as seen from the percentage baseline values normalized to 100% (Table 2).
RNASEL is a key component of the innate immune system and participates in the process of apoptosis [ 19], but the functional effect of rs672527 is unknown.
They used the scores to identify mutations which cause hyperactivation or gain-of-function outcomes, but our work uses not only the functional effects of mutations but also several other properties.
To date, the degree of endothelial damage only has been evaluated on a cellular and molecular level, but no studies exist looking at the functional effects of CPB on the endothelium.
Cysteines at the more extracellular sites appeared to react with all (334, 335, and 338) or nearly all (331, 333, and 336) of the reagents utilized here, but there were distinct differences in the functional effects at different locations.
Similar results characterize the functional effects of the D76N mutant.
The next experiments examined the functional effects of adding AMPAR-dependent plasticity to CA1 pyramidal cells.
The functional effects of these ten individual FOL compounds were also tested using electrophysiology.
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