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RNASEL is a key component of the innate immune system and participates in the process of apoptosis [ 19], but the functional effect of rs672527 is unknown.
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A subset of these SNPs are associated with quantitative expression of nearby genes, but the functional effects of the majority remain unknown.
CGH in principle defines only the chromosomal structural changes, but the functional effects of CNAs can be reflected by altered gene expression.
Also, in peripheral nerves of laminin α2 deficient mice, laminin α1 can be detected [ 53, 54], but the functional effects of this compensatory upregulation are not yet clear.
The significance of the LPS-triggered death of lytically infected DCs is unclear - these stimuli are hardly a physiological combination - but it made clear that the functional effect of such stimuli on virus-exposed DCs cannot be interpreted without some measure of viral gene expression.
As for receptors, tuning the functional effect of binding is even more important.
However, the functional effect of abolishing glycosylation on the receptor is unknown.
The functional effect of myostatin inhibition on the dystrophic heart was determined by echocardiography.
We next determined the functional effect of removing the entire C-terminus (CSpt5).
Altogether, the functional effect of TN122 is limited.
The functional effect of ERCC2 polymorphisms remains unclear.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com