Sentence examples for but the functional consequence from inspiring English sources
Fullerene nanoparticles have been reported to specifically bind to and elicit persistent activation of hippocampal Ca2+/calmodulin-dependent protein kinase II (CaMKII), a multimeric intracellular serine/threonine kinase central to Ca2+ signal transduction and critical for synaptic plasticity, but the functional consequence of that modulation is unknown.
Previous work showed that dysferlin recruits PARVB to the sarcolemma.[42] PARVB can directly interact with integrin linked kinase, and is important for stabilizing focal adhesions.[52], [53] In the absence of dysferlin PARVB does not localize to the sarcolemma, but the functional consequence of this is unknown.[42] Calpain 3 is also in complex with dysferlin.
CK1α phosphorylates Ser45 but the functional consequence of this phosphorylation is not well understood.
More than 1000 SNPs have been identified in ESR1, but the functional consequence of each SNP has not been characterised.
Several serine/threonine kinases, such as PKA, GSK3, CK1 and DYRK2, can directly phosphorylate Gli2, but the functional consequence of these phosphorylations is connected to processing and degradation of Gli2 [48,49].
These results are consistent with previous findings that motor impairment in and of itself does not reduce health-related quality of life but the functional consequences of poor motor function including loss of self-care capabilities, inability to ambulate and loss of independence and its emotional consequences that may provide the link between physical impairment and low HRQoL [ 16, 35].
In schizophrenia, GAD67 downregulation occurs in multiple interneuronal subpopulations, including the cannabinoid receptor type 1 positive (CNR1 +) cells, but the functional consequences of these disturbances are not well understood.
One likely explanation is that CB4 is recognized by TLRs other than TLR3 but the functional consequences of this interaction are not critical for survival.
