Sentence examples for but sustained activation of from inspiring English sources

Also, genistein induces a late but sustained activation of the eNOS system in vitro [15].

A model consisting of a single pair of interacting agents predicted very different Erk activation (phosphorylation) profiles, depending on the formation rate and stability of intercellular contacts, with the slow formation of stable contacts resulting in low but sustained activation of Erk, and transient contacts resulting in a transient Erk signal.

This model was selected due to its relative simplicity compared to other more detailed descriptions, although this does not impact on its ability to predict key features of the pathway, notably the high amplitude transient peak in activated Erk, followed by a lower, but sustained activation for periods of several hours.

The lower panel of Fig. 1B demonstrates that similar to rat T cells [11] ANC28.1 induced a weaker and delayed but clearly sustained activation of PLCγ1 when compared to stimulation of human T cells with CD3 mAb.

Decellularized ECM suppressed the phosphorylation of focal adhesion kinase (FAK) [ 38] but induced sustained activation of MAPK and the downstream extracellular signal regulated kinases 1 and 2 (ERK1/2) [ 19].

Collectively, the data suggests that Foxo, Rb, and p53 control the hazardous effects of moderate ROS generation during normal stem cell maintenance but that sustained activation of these pathways contributes to stem cell dysfunction.

Our previous study showed that either TGF-β1 alone or H2O2/HOCl only induced the transient, but not the sustained, activation of Smad, p38 MAPK, and ERK pathways.

The model used here considers another difference attributed to a sustained activation of another activator of the MAPK cascade, Rap1, by NGF but not by EGF [ 24, 37].

This agent induces sustained activation of mitogen-activated protein kinases (MAPK), including JNK and p38 MAP kinases.

Thus, NS-associated SHP2 mutants display increased phosphatase activity and promote sustained activation of the RAS-ERK1/2 pathway.

We found that WT FGF1 induced sustained activation of ERK1/2, but R50E was defective in this function.