"The human ear-brain system is good at discerning changes in sound level," Choueiri explains, "but subtle changes in the relative timing between the wave components of a sound are too subliminal for humans to detect.
Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets.
Further, the StarD3 ligand, lutein (Li et al., 2011), did not alter cellular levels of StarD3, suggesting no changes in stability/degradation of this protein, but subtle changes in sterol metabolism were observed in cells exposed to this carotenoid.
In both null lines, reproducible but subtle changes in cell cycle distributions were observed, most notably a reduction in the proportion of cells in G2/M (Fig. 2E), suggesting that these cells are cycling slightly more slowly than controls.
We found evidence of significant but subtle changes in richness over the 22-year study period for Neotropical migrants (annual trend of −0.036×22 years = −0.79 species per route), permanent residents (+0.84 species), and cavity nesters (+0.37 species) (Table 1; Figure 2a,b).
Our results provide insight into the ancestral Xanthomonas genome and indicate that differentiation with respect to host- and tissue-specificity involved not major modifications or wholesale exchange of clusters, but subtle changes in a small number of genes or in non-coding sequences, and/or differences outside the clusters, potentially among regulatory targets or secretory substrates.
Greenfield said there was a need for work to be done, but measuring subtle changes in the brain was extremely difficult.
Ms. Kidman didn't deviate from the text, but made subtle changes in her inflection, giving the moment, in which she reveals that she no longer wants to attend a support group for grieving parents, a tinge of sadness or bitter resignation.
But Cooks' subtle changes in direction are becoming less subtle with time, and now we just have to sit back and watch to see what comes out of that quiet rerouting.
The results are not gross structural changes but rather subtle changes in local conformation and flexibility at the PPIase catalytic site that fine-tune binding affinity and isomerization activity.
In this regard, it has been described that not only acute NF-κB activation is related with disease but also subtle changes in NF-κB activity that persist in time have important biological consequences, giving rise to chronic inflammatory conditions.
