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After a preliminary trial in 1986, standard therapy for HCV consisted of subcutaneous injections of 3 million units of interferon-α three times a week for 24 weeks, 10 but subsequent optimization of treatment recommended the extension of therapy duration to 48 weeks in some patients and the addition of ribavirin 800 mg/day.
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It aims to define industrial ready product through two necessary passages: the preliminary design of an optimized ideal system, which is used a term of comparison to define the possible direction of evolution to optimize the product, and the subsequent optimization of the components considering them as inserted into the relative flux.
Subsequent optimization of the multifunctional nanoprobe will offer new possibilities for cancer diagnosis and treatment.
Subsequent optimization of GLUT5 ligands as selective and potent in vivo chemical probes will allow for advancement of our understanding of GLUT5 biology, its role in human disease, and ultimately its pharmaceutical control.
These warheads could then be used as hit structural templates in the subsequent optimization of inhibitors recognition sites.
Subsequent optimization of b2 based on docking analysis and structure-based drug design knowledge resulted in d1.
The solution method presented can be adapted for the sensitivity analysis and subsequent optimization of a large number of adsorption systems.
Although some limitations are observed, the model represents in a precise manner the real temperatures in the process, providing the basis for a subsequent optimization of the process.
In addition, SIC allows the selection of specific solution conditions (including detergent type and concentration) for subsequent optimization of protein solubility, homogeneity, and crystallization.
Subsequent optimization of the resulting compound gave the potent agonists 25c, 30b, and 30c with high metabolic stability and significant antidiabetic activity.
The exergy based performance evaluation and subsequent optimization of LHTS units have been a growing interest among the researchers in recent years.
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