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N -acetyl transferase (NAT 1 and NAT2 proteins were expressed by all three MCF-7 sub-lines, but significantly higher expression of NAT2 was accompanied by enhanced acetylation efficacy in MCF-710 nM 126cells.
These included the serotonin receptor 1a (Htr1andand cholinergic receptors, muscarinic receptor 2 (Chrm2) and nicotinic receptor alpha 7 (Chrna7), which showed small but significantly higher expression in the P/FC of the FSL animals, while serotonin receptor 2a (Htr2a) was expressed at higher levels in the HIP of FSL animals.
In contrast, genes with high methylation in their gene bodies (5 kb or more downstream of TSSs) had slightly, but significantly, higher expression levels (right panel).
Moreover, comparison of mRNA expression levels between AC and SCC revealed no difference in PHC3 mRNA levels in non-malignant tissue, but significantly higher expression in SCC tumours relative to AC tumours and SCC tumours relative to matched non-malignant tissue.
With the exception of marginal but significantly higher expression of TLRs 1 and 3, most of the TLRs investigated were comparable in their magnitude of expression in the epidermis after birth (infants and children) when compared with adults (Fig. 1B, and data not shown).
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Most genes identified as female-biased in the brain were expressed in both sexes but with significantly higher expression in females.
GCN4, EAP1, and TES2 were upregulated in both PK + C.a.3 h and C.a.3 h samples, but with significantly higher expression in PK + C.a.3 h.
FOXF1 showed no difference in expression between NP and AF cells, but both cell types demonstrated significantly higher expression than did AC cells (P < 0.0001).
On the contrary, the GMS mutant anthers at the tetrad stage had similar (in Gh-miR167) or lower (in Gh-miR396 and Gh-miR398) expression levels of the miRNAs, but their target genes had significantly higher expression levels, as compared with the WT.
The reason for this is unclear but may be associated with a significantly higher expression of interleukin 1 receptor antagonist (IL1Ra) in the co-cultured or BMSC pellets relative to MC pellets prior to IL-1β treatment since IL1Ra has been implicated in mitigating the pro-inflammatory effects (i.e. inflammation and fibrosis) of IL-1α in mice lungs after treatment with BMSCs [ 44].
Figure 4C illustrates that animals treated with UA/OA exhibited a higher (but not significantly) expression of both cytokines and a significantly higher expression of iNOS than non-treated control animals.
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