Due to its rare, but significant side effects, it's only approved for women with diarrhea-predominant IBS and you must be enrolled in a special program.
GnRH analogues may be used as second-line treatment, but significant side effects should be taken into account.
BiPN is one of the most common, often reversible, but significant side effects of bortezomib therapy, which leads to dose modification [ 3– 6].
The role of inflammation in DED makes topical corticosteroids a natural candidate for therapy, but significant side effects with prolonged corticosteroid therapy, including secondary glaucoma, infection and cataract formation, have limited their use.
In theory, this is a performance-enhancing benefit, but a significant side effect, as a teammate on my university track team discovered, is explosive diarrhea.
Clonazepam as a topical and systemic agent has been evaluated with mixed outcomes [54, 55] but the significant side effect of drowsiness and the potential for addiction need to be taken into account.
Zymogenetics (in collaboration with Bristol-Myers Squibb) assessingsing PEG-IFNλ1 in clinical studies which, while showing promising antiviral activity, have also uncovered a different but nevertheless significant side effect profile from that seen with IFNα.
Such drugs increase the risk of skin cancer, diabetes, and a type of lymphoma, but Owen says Hallam's only significant side effect so far was a "touch of diabetes" that went away once his drug doses were adjusted.
No significant side effect was seen during the trial.
Sunitinib is associated with a significant side effect burden.
