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Administration of M35 itself caused a slight but significant reduction of basal extracellular 5-HT at 120 min (p <.05).
Down-regulation of GPR83 in the POA resulted in a small (0.15 °C) but significant reduction of CBT during the dark/active cycle of the day.
The selective EP4 receptor antagonist ONO AE3 208 (300 nM) (which showed no effect on its own, data not shown) caused only a small, but significant reduction of barrier enhancement, as did the pretreatment of the epithelial cells with 10 µM diclofenac (Fig. 5a,b).
Administration of M35 itself caused a slight but significant reduction of basal extracellular 5-HT at 120 min, which is in agreement both with in vitro data in insulinoma cell lines (Kask et al. 1995) and in vivo data showing a partial agonistic mode of action of M35 (Antoniou et al. 1997).
Conclusions: The results suggest that nutrition labels on pre-packaged foods in a large university dining hall produces a small but significant reduction of labeled high calorie and high fat foods purchased and an increase in low calorie, low fat foods.
There was a small but significant reduction of mitochondrial membrane potential (state 4) only in the presence of the pathological-length polyglutamine tract.
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QMF149 treatment was also associated with a numerical, but not significant, reduction in the risk of serious asthma exacerbations.
Assays of reporter gene activity following gene knockdown yielded modest but significant reductions of NF-κB transcriptional activation for all three knockdowns when cells were treated with TNFα, though no significant change was observed between control and specific siRNA treatments in the absence of this stimulator.
In addition, slight but significant reductions of FPG and fructosamine were observed in the GFT505 group.
At 100 μℳ MET, we did observe small but significant reductions of Akt-S473 phosphorylation, total mTOR and phosphorylated 4EBP1 levels.
Thus, even though the prevalence of daily smoking had been rapidly decreasing and there were smaller, but significant reductions of the proportion of non-daily smokers (from 12.2 to 8.1%, P < 0.001), the relative proportion of non-daily smokers who were using snus on a non-daily or daily basis had tripled.
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