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Slight but significant increases of the nc-rRNAs in adherent cells from LNA1-S treatment compared with either vehicle or LNA1-AS may have been a result of upregulated transcripts from dying cells that have not yet detached.
This is also corroborated by immunoblotting of LAMP1 and another lysosomal enzyme, CTSD, which reveal that TFEB injection is associated with mild but significant increases of these lysosomal protein levels (Fig 6C and quantified in 6D).
They also found that female human patients with the neurodevelopmental disorder Rett syndrome (who have a natural deficiency of MeCP2) have small but significant increases of L1 insertions in their hippocampi.
In a secondary analysis when IG was defined by IFG only, IGT only, or IFG and IGT combined criteria, no significant increase in typ, atyp, or combined typ and atyp DPN was observed whether narrowly or broadly defined; however, small but significant increases of retinopathy and nephropathy were observed.
By these measures, Hyp:Pro changes after coadministration of TGF-β2 and CTGF were most dramatic in kidney and liver (increases of 65%andd 160%, respectively, over control,), with more moderate but significant increases of 34%and11%1% being seen in heart and lung, respectively (P < 0.001 in kidney, liver and heart, P < 0.01 in lung).
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A small but significant increase of base flows, maximum flows and number of peak days was identified.
There was, however, a small but significant increase of 3.5% in PHDD for the social drinkers following laboratory testing.
Interestingly, a treatment with this ER-ligand, caused moderate but significant increase of CYP1A mRNA expression (about 2.5-fold; P < 0.05).
The delivery of neurotrophins lead to mild functional improvements in the ischemia-induced motor impairments assessed 3 5 weeks after the insult, in agreement with a small but significant increase of the survival of dorsolateral striatal neurons.
An increase in compressive stress results in a small but significant increase of the onset temperature of the γ → α transformation and a decrease of the overall transformation time.
A small but significant increase of 20 mV (up to 580 mV), as compared to the pure indium sulfide buffered cells is possible leading to an increase in the overall efficiency.
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