We found a small but significant increase in homology between breakpoint pairs compared to a random expectation, supporting NAHR as a main mechanism for formation of CNVs in canids.
Our data suggest a slight but significant increase in blood lead between baseline and 6 months after a bilateral oophorectomy.
When these effects were quantified we found a small, but significant increase in the distance between primary branch points at 4, 5 and 6 weeks.
We observed a small but significant increase in blood lead between the baseline assessment and the 6-month postsurgical visit, particularly for women who were not on ERT after the surgical menopause.
Finally, the nonchemotherapy group also had mean scores lower than the healthy control group at baseline (37.64) but showed a steady increase over time with an overall significant increase (F=13.34, P=0.001) but no significant increase between consecutive time points.
Upon treatment with saturating amounts (10 μM) of the full agonist isoproterenol, a small, but significant, increase in FRET was observed between TM6 and H8.
There was also one dog with only a slight increase in GLDH at examination 1 and another dog with a high ALT value at examination 4. Of the 34 dogs, 12 were treated with glucocorticoids and in this group a minor, but significant, increase in ALP was seen between examinations 1 and 2 (p < 0.05, sign. test) (Fig. 4).
In Se-supplemented women alone, a small but significant increase in GPx3 activity was found between 12 and 20 weeks, which was also observed between 12 and 35 weeks, despite a modest decrease between 20 and 35 weeks.
We observed a small but significant increase in median blood lead levels between the baseline visit and the 6-month visit (0.4 μg/dL, p < 0.0001), particularly for women who were not on estrogen replacement therapy (0.7 μg/dL, p = 0.008).
