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Nodal micrometastases appear to have a small but significant adverse effect on distant recurrence and survival in some studies, but not in all [ 16].
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Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility.
However, the authors concede that small sample sizes would greatly impair the ability to observe rare but significant adverse effects.
The absence of benefit together with the risk of infrequent but significant adverse effects suggests that there is little indication for vitamin D supplements in patients with sarcoidosis and vitamin D levels in the range in this study (12 49 nmol/L).
The overall conclusion of that report was that, at levels of exposure in some fish- and marine mammal-consuming communities (including those in the Faroe Islands and New Zealand), subtle but significant adverse effects on neuropsychological development were occurring as a result of in utero exposure.
These slopes should not be used to extrapolate beyond the group sizes used in these trials, but they nonetheless demonstrate a significant adverse effect of intersex on reproductive performance.
Intel, a Nasdaq heavyweight, said that the Internal Revenue Service was auditing its tax returns for 2001 and 2002, but it thought that the outcome would not have a significant adverse effect on its finances.
Climate change can have a significant adverse effect in the short term.
And 22percentt of all those surveyed said there was a significant adverse effect on their health.
"A profound decrease in slow-wave sleep had an immediate and significant adverse effect on insulin sensitivity and glucose tolerance".
Earlier, Watson told councillors that the scheme would have a significant adverse effect on the local area, whose residents were overwhelmingly against it.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com