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Previous studies have shown a small but significant additive effect of caffeine for the control of headache and non-headache pain [5, 6].
This indicates that ABT-737 and Bortezomib can effectively reduce melanoma tumor growth in vivo, and that combining them at these doses has a small but significant additive effect.
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The QTL cp1, which was detected only in the 2004/2005 trial, and cp6 showed minor but significant additive effects (Table 1).
It was demonstrated that the combination treatment produced small but significant additive effects on the inhibition of cell growth compared with ABDP as a single agent after short-term (7 days) challenge, that is, mean decrease 17.2%, CI=12.2 22.2, P<0.001 at 0.1 μ M ABDP, mean decrease 10.2%, CI=7.2 13.2, P<0.001 at 0.25 μ M ABDP and mean decrease 18%, CI=11 25, P<0.001 at 0.5 μ M ABDP.
Immunotherapy itself provided no clinical benefit by itself as compared with chemotherapy, but a significant additive effect of immunotherapy on chemotherapy was observed in females with adenocarcinoma.
Consequently, Mn2+ promotes further differentiation at low ECM concentrations (by activating those integrins not already activated by the ECM) but has no significant additive effect at the high ECM concentrations.
The mRNA expression and protein levels of cyclin D1 in the non-adherent cell populations were analyzed at days 2, 4, 6 and 8. Cyclin D1 mRNA expression (Figure 3A) and protein levels (Figure 3B) were increased with Flt-3L but there was no significant additive effect with PTH treatment.
In addition, no significant additive effect on MAG-Fc protection was observed on cells infected with both particles.
Interestingly, OleTJE-RhFRED retained its ability to use H2O2 as a cofactor, but there was not a significant additive effect between NADPH and H2O2 for supporting the activity of OleTJE-RhFRED.
The deletion in exon 9 of CSN1S1 (SNP11), which results in the absence of detectable αS1-casein [ 12], did not show any significant additive effect, but also did not follow the pattern of the neighbouring SNP.
More surprisingly, for silking date and plant height, results for the QTL obtained on the NCIII designs and on the global design were not consistent, since a majority of QTL were detected for Z2 whereas most QTL detected on the global design presented a significant additive effect but only 15 of 27 showed a significant dominance effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com