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These results are in line with our previous observations that that activation of microglial cells with different proinflammogens led to modest but significant activation of caspase-8 activity in absence of significant cell death [ 20].
Transient gene expression assays of increasing concentrations of plasmids encoding WT or MT RSPO1 showed a modest but significant activation of the TOPFLASH reporter vector for the WT (maximal 1.8-fold) and a complete lack of activity for the p.Ile32_Ile95del mutant plasmid (Fig. 3A).
Our present results (Fig. 2C) show that H2O2 did cause a small but significant activation of the RG mutant after 10 min, but that this had reverted to baseline by 60 min, which is why we previously missed it.
Using a similar co-transfection strategy, we found a small but significant activation of the all three promoters with the predicted AT motif by ZFHX3+ but not for the Cry1 promoter.
Thus, the main finding of this overview is that amlodipine (despite its "positive" profile in clinical outcome studies) caused a small but significant activation of the sympathetic nervous system, as assessed by multiple markers.
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BNF did not significantly activate AHR in the duodenum and jejunum, but exhibited significant activation of AHR in the ileum.
In fus3∆ cells, a weak but statistically significant activation of the pathway can be detected.
12 13 27–34 The limited literature on the brain effects of LA suggests limbic-paralimbic-neocortical activation but no significant activation of the somatosensory cortex.
We observed that treatment of cells with Triphala caused subtle but statistically significant activation of ATM as evident by phosphorylation at Ser 1981 (Fig 2A).
The dansyl derivatives of NECA elicited Gi-mediated responses, but no significant activation of Gs-mediated responses was observed over the concentration range studied (Table 5; Figure 6).
This additional level of abstraction, it is argued, will lead to recruitment of the pre-PMd, red region B in Figure 1, but no significant activation of the more anterior lateral frontal regions.
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