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Strengthening the research capacity of developing countries is essential to reduce inequities in health, but requires the development of institutional and regulatory frameworks, infrastructure, investment, and a sufficient number of skilled people to conduct and publish research [ 2, 4].
To establish cost-effective fermentation of lignocellulosic biomass, the consolidation of sacccharification and fermentation processes is a desirable strategy, but requires the development of microorganisms capable of cellulose/hemicellulose hydrolysis and target chemical production.
For example, a laminar flow within tubular structures located within a scaffold may be beneficial for the generation of large TE constructs but requires the development of advanced bioreactor systems.
A consensus on the indication for TKA in knee osteoarthritis (KOA) is in high demand, but requires the development of high quality evidence for the treatment options in KOA.
In contrast, the new approach adopted in this explorative study arose from the belief that a reintegration of personal satisfaction cannot be obtained only from reducing symptoms or improving quality of life, but requires the development of more functional and mature ways of facing reality and its stressful situations, such as severe illness.
Combining the steps of enzyme production and sugar fermentation in a one-step process called consolidated bioprocessing (CBP) has the potential to address this limitation but requires the development of an organism that both degrades cellulose efficiently and produces fuel at high yield and titer [ 4].
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Remote sensing techniques provide a potentially low-cost alternative to field-based assessment, but require the development of methods to easily and accurately extract the required information.
Engineered ligament tissues are promising materials for the repair of tears and ruptures, but require the development of biomaterial scaffolds that not only support physiologically relevant loads, but also possess architectures capable of orienting cell adhesion and extracellular matrix deposition.
In principle the flux of accelerated particles can be made higher than in a reactor, but this requires the development of new, even higher power accelerators.
Patient-centered medicine implies a paradigm shift in the relationship between doctors and patients, but also requires the development of patient-oriented research.
Not only this issue has not yet been investigated, but it also requires the development of a specific contribution game, since the possibility of a target has not been explored in the theoretical literature.
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