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Chip-based exome capture was the first to be developed [ 6, 7], but required large amounts of input DNA, and was quickly replaced by more efficient solution-based capture systems.
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It is easy to forget, especially in the post-9/11 United States, that the greatest political victories were rarely won through elections but required large-scale political mobilization.
Discrete element modeling of granular flows is effective, but requires large numerical models.
Fourth, not merely allow but require large banks to issue and regularly reissue a particular form of subordinated debt.
Using low-pressure steam gives high acrylic acid yield and lower carbon dioxide generation but requires large reactors.
Mesic vegetation such as lawns reduces urban temperatures by evaporative cooling but requires large amounts of water for continuous irrigation.
Thermal modulators produce narrow peaks at optimal flow rates, but require large amounts of consumables or a highly engineered heating/cooling system.
This lay-out achieves very high net electric efficiency (about 40%), but requires large membrane surface area with penalties from economic point of view (cost of CO2 avoided about 50% higher than reference case).
Currently used sensible energy storage systems (commonly using water as the storage medium) are simple and inexpensive, but require large amounts of storage material, and therefore are heavy and take up considerable space.
Ankle function might be restored by powering the joint directly, a technique that shows promise [8] [10] but requires large motors and energy sources that limit range or add bulk.
Pumpless systems result in less blood trauma, but require large bore arterial cannulas and an adequate cardiac output.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com