Aged Dlx2+/Dcx+ neuroblasts, on the other hand, increased express of "calcium, magnesium responsive genes" among others, but reduced expression of "telomere maintenance" genes as well as a lot of "cell cycle" genes including Mki67, Melk, Mapk1 (Figs. 6A, 6F, 6G, and S2A).
BAF and HMGA1 proteins were also shown to stimulate HIV PIC integration activity, but reduced expression of these genes showed no effect on HIV infection efficiency [38], [39], [40], [41].
Exogenous OLFM1 increased expression of SNAI1, ZEB1, ZEB2 and SOX9 but reduced expression of SNAI2 (Fig. 7B).
The synergistic effects also led to increased expression of the pro-apoptotic protein, maspin, but reduced expression of the anti-apoptotic protein, survivin.
Surprisingly, there were similar levels of COX8b, LSDP5 and UCP1, but reduced expression of ELOVL3 in the BAT of FSP27-/ mice.
We observed expression of the osteogenic gene Runx2 (mapped on 6p21 – i.e. large chromosome, telomeric) but reduced expression of the soft tissue markers.
Despite enhanced TNF-α expression, suppression of TNFR-1 or SHP-1 by siRNA delivery not only enhanced expression of angiogenic factors (KDR/Flk-1 and eNOS) and anti-apoptotic factor (Bcl-xL) but also reduced expression of a pro-apoptotic factor (Bax).
Our microarray results showed a slightly but consistently reduced expression of the complete GTA gene cluster in all three mutant strains.
In dexamethasone-treated rats, testosterone reversed dexamethasone-induced changes in expression of FOXO1, but also reduced expression of REDD1 and 4EBP1 [ 42], genes that were not found to be nandrolone responsive in denervated muscle.
In particular, mocetinostat treatment not only strongly upregulated miR-203, but also reduced expression of ZEB1 on both mRNA and protein level (Fig 3B and C, Supplementary Figs S2F and S3A).
Only a small fraction of ACFs and adenomas showed reduced Fhit, but reduced expression was strongly associated with degree of dysplasia.
