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Therefore our data suggest that under LD conditions appropriate Shaw-mediated electrical activity is not required for rhythmic output from the clock, but rather regulates overall behavioral activity levels with the DN neurons being particularly important for this regulation.
It is therefore unlikely that ADAMTS-12 promotes an invasive phenotype directly through an RGD-dependent interaction, but rather regulates the function or expression of proteins capable of controlling RGD-mediated cell-matrix adhesion and cell invasion.
Dab2 has no effect on the rate of LRP6 internalization but rather regulates its interaction with caveolin or clathrin.
Golli-BG21 does not affect the IP3-dependent release of Ca2+ from internal stores, but rather regulates store-depletion-induced Ca2+ entry itself [ 24].
Altogether, our data show that ubiquitination of SopB is not related to its intracellular stability but rather regulates its enzymatic activity at the plasma membrane and intracellular localization.
However, other studies have found that ZAP-70 does not directly interact with Vav1, but rather regulates the phosphorylation and interaction of SLP-76 with the Vav1 SH2 domain [ 21, 39].
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The California attorney general said that the law did not inhibit free speech, but rather regulated the conduct of licensed professionals, and that the government had an established interest in barring practices deemed ineffective or potentially harmful.
The hormones and diets known to regulate WNK OSR1/SPAK signaling (Fig. 2) may not directly regulate WNK but rather regulate KLHLs, thereby regulating WNK kinase.
Moreover, we find that a large fraction of the driver mutations are neither located in conserved functional sites, nor responsible for structural stability, but rather regulate protein activity through allosteric transitions, protein-protein interactions, or protein-nucleic acid interactions.
It is becoming clear that Wnt molecules do not simply drive proliferation or differentiation, but rather regulate and fine-tune these processes in a cell-type and time-dependant manner.
He reviewed a number of interesting candidates, including regions of the genome that do not appear to code for specific peptides but, rather, regulate transcription of other genes (4).
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