What the University of Wisconsin-Madison study may ultimately show isn't the negative power of a comment in itself but, rather, the cumulative effect of a lot of positivity or negativity in one place, a conclusion that is far less revolutionary.
Therefore, the main cause of ARF may not be the medication itself, but rather the cumulative effects of polypharmacy.
Therefore, the changes in triacylglycerol levels seen in the current study were probably not due to one day of exercise but rather a cumulative effect of several exercise sessions as no differences were reported in a previous study between one bout of exercise at 24 and 48 hours [ 53].
No evidence exists that prior exposures to toxic agents prevent intoxication from later exposures; rather, cumulative exposures to most toxicants increase risks of adverse health outcomes.
Building on this simplification, we do not model the effect of single administrations of either TKI or IFN α but rather describe their cumulative effect within the bone marrow as a binary/on off variable.
Furthermore, the values for the parameters c d and V pd must be assumed because the regulation U pd is not associated with any specific enzyme but rather represents the cumulative effect of degradation regulation.
First, when we see a significant partial correlation between the genes, it might be caused not by their direct interactions, but rather by the cumulative effects of variation elsewhere in the network that we have not accounted for.
The combined results strongly support the notion that Fatq2 is not the result of a single QTL with one large effect, but rather the combined cumulative effect of at least two QTL each with a smaller contribution to TF, shown by the reduced TF of cast/cast mice from the HG2D-3 and HG2D-5 strains.
18, 70– 72 However, such increases of TGF-β1 levels are not specific for aortic disease, but rather relate to the cumulative severity of organ involvement in MFS.
These data suggest a lack of complete redundancy between let-7 microRNA species, but rather a precisely regulated cumulative dose that when increased or decreased, leads to significant alterations in regenerative capacity.
