Still, even before the Evolution publication, some scientists believed that it might be possible to approximate dinosaurs, only not recovering their genetic information, but rather by functionally reversing their evolution.
This finding suggests the enriched non-coherent GO processes are not isolated events, but rather functionally consistent phenomena mediated by miRNA.
In this case aligned positions do not represent homologous residues, but rather functionally analogous residues.
Although both parameters reflect deregulation of gene expression, they are not randomly but rather functionally related.
There is increasing evidence supporting the hypothesis that MLL fusion partners are not randomly chosen, but rather functionally selected.
However, newer prognostic signatures, not dependent on proliferation gene modules but rather functionally linked to immune/inflammatory and chemokine pathways, have been proposed as metastatic risk predictors for HRneg/Tneg breast cancers.
These reports however, did not use this biological information as a filter for the coevolutionary analyses but rather as a criterion adopted a posteriori to performing the method to detect functionally important coevolving pairs.
Typically, proteins do not act in isolation, but rather perform their functions cooperatively within a network of functionally related proteins.
This can be understood in terms of the model proposed by Dehaene et al. [29], in which the fusiform visual word-form region is not functionally homogenous, but rather exhibits a gradient of increased sensitivity to larger and higher-level components as one moves from more posterior structures to more anterior ones.
Think of it this way: would you rather live in a functionally secular western country, or in one where the moral climate is much more influenced by what (among others, religious) leaders say it should be?
