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But randomized controlled trials exist there, too.
But randomized controlled trials are not always possible, so researchers sometimes turn to a statistical approach called the method of instrumental variables to rule out other potential factors that could account for different outcomes between groups.
At the time of writing only dopamine agonists are licensed for the treatment of restless legs syndrome (RLS) in various countries, but randomized controlled trials (RCTs) have been performed with other treatments.
Epidemiological studies showed that low 25-hydroxyvitamin D levels are associated with a significantly increased risk of arterial hypertension and cardiovascular events, but randomized controlled trials (RCTs) could not document significant and consistent effects of vitamin D supplementation on blood pressure or cardiovascular events.
BACKGROUND: The colony-stimulating factors (CSFs) are widely utilized to prevent neutropenic complications in both adults and children, but randomized controlled trials in the pediatric setting have reported varied results.
the mainstay of treatment of polymyalgia rheumatica (PMR) is oral glucocorticoids, but randomized controlled trials of treatment are lacking.
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3 Large prospective cohort studies, but not randomized controlled trials, report that consumption of whole grains is associated with a reduced incidence of type 2 diabetes.
We conducted a cross-sectional study of 1224 patients with hypertension utilizing baseline data from two separate, but similar randomized controlled trials.
It was not a clinical trial, but two randomized controlled trials of treatment of mild GDM have been carried out successfully in participants with glucose values that overlap with the thresholds recommended in this report.
One study showed effectiveness of a home exercise program in reducing shoulder pain in construction workers [ 17], but further randomized controlled trials are needed to evaluate the effect of workplace exercise interventions on shoulder, arm and wrist pain [ 10].
For neurocritical care patients, most research has been conducted for traumatic brain injury and subarachnoid hemorrhage, documenting associations for lower Hb-levels with poorer outcome, but large randomized controlled trials (RCT) are missing [ 2- 4].
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