The causes are not known but probably include a combination of inherited bad genes, bad diet (too much fat and red meat, too few vegetables) and random genetic errors that occur as cells divide.
The authors of the initial criticisms are unknown, but probably include the Dionysius who is named as author of replies to the Epicurean rebuttals of the first round of criticisms (§1, vii 5-viii 21; Zeno's replies occupy viii 21-ix 26), and he may be a Stoic or Peripatetic.
Coupling in the papilla is unlikely to be purely elastic, but probably includes partially viscous elements.
The full repertoire of functions of DJ-1 is unknown but probably includes oxidant signalling with mitochondria.
Downstream targets remain obscure but probably include ectodysplasin-A, which promotes placodal cell fate along the mammary line when overexpressed [ 49].
The disease seems to be extending to previously malaria-free, highland fringe areas, for reasons that are not well understood but probably include drug and insecticide resistance, changes in land use, population movement, and other ecological changes (3).
The endogenous sources that contribute to the generation of reactive oxygen intermediates in acute lung injury are poorly defined but probably include the molybdenum hydroxylases, NAD(P H oxidoreductases, the mitochondrial electron transport chain, and arachidonic acid-metabolizing enzymes.
It should also be emphasised that the evolutionary change is not just the result of habitat-related selection, but probably include other kinds of genetic differentiation (for example, founder events and genetic drift) as well.
The findings are in contrast to those of a previous analysis of the DCCT data, which suggested that A1C variability had little effect on complication risk (3), but probably included all patient visits, including those before A1C stabilized at 6 months in intensively treated patients.
