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The main outcome measures were 30-day risk of MACE (non-fatal acute myocardial infarction (ICD-10 code I21), non-fatal ischemic stroke (ICD-10 code I63 64; I64 refers to unspecified stroke, but previous data have demonstrated that the majority of these strokes are of ischemic type) (Krarup et al. 2007) or cardiovascular mortality (ICD-10 codes I00 I99)), and all-cause mortality.
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Although increased overall mortality in PsA patients has been reported in some [ 29- 32] but not all [ 33, 34] studies, previous data have consistently indicated an increased susceptibility to CVD and related mortality in PsA patients [ 3, 35].
In this scenario, the absence of Numb is expected to impair p53 stabilization but not to alter T-cell specification, as previous data have shown, as loss of p53 apparently does not affect thymocyte development.
Previous data have shown that LY450139 lowers plasma Aβ, but has no clear effect on Aβ1-40 or Aβ1-42 levels in cerebrospinal fluid (CSF).
Previous data have shown that a citrus flavanone, hesperidin possesses chemopreventive efficacies.
Previous data have shown that host genetics play a role in disease susceptibility and severity.
Previous data have shown that host genetics also play a role in disease outcome.
Previous data have shown that some of these events are independent from each other.
Previous data have shown a positive association between Glo1 expression and anxiety-like behavior across 6 inbred strains [7].
Previous data have indeed implicated such enzymes in tissue protection during hypoxia [27], [28], [29], [30], [31], [32].
Previous data have demonstrated a beneficial role of acute GSK-3 inhibition in the treatment of diabetes and obesity.
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