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CHC22 has been shown to be able to substitute for CHC17 function and mediate CCV-dependent transferrin internalization, but only when expressed at high levels (comparable to wild-type CHC17 expression levels) and in the absence of endogenous CHC17 (Liu et al., 2001; Towler et al., 2004; Hood and Royle, 2009; Esk et al., 2010; Brodsky, 2012).
Efficient designs can be constructed that allow adjustment for carryover effects, but only when expressed in particular, limited, mathematical forms.
E2F4 and E2F5 can exhibit oncogenic activity, but only when expressed together with other oncogenes such an activated mutant of Ras [11], [23].
In contrast, the converse chimeric protein with a substitution of the Roc1b RING domain with that of Roc1a can rescue the male sterility of Roc1b mutants, but only when expressed from the endogenous Roc1b promoter.
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At 3 years the improvement in VO2max persisted only when expressed in absolute terms but not when expressed per unit body mass.
In contrast to the E2-G60D, the mutation E2-I211T sincreasestly infectivitynfectivity of the Ag41855 strain for Ae. albopictus only when expressed together with the E1-226V mutation.
This result indirectly suggests that AtPP2-A1 plays a role, only when expressed itself, in repressing the phloem-feeding activity.
In fact, it may turn out that certain antagonists act as such only when expressed at nonphysiological levels.
This result indirectly supported that AtPP2-A1 plays a role, only when expressed itself, in repression of the phloem-feeding activity.
In this system, the Cre is fragmented into two non-functional fragments and becomes active only when expressed in the same cells.
HOXA9 expression was found to cause transformation of normal hematopoietic cells to AML cells only when expressed together with MEIS1 (Kroon et al., 1998).
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