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The alternative splicing affects the enzyme regulation by phosphorylation, but only modest differences in the catalytic properties of the isoforms have been reported [Haavik et al., 1991; Nasrin et al., 1994; Gordon et al., 2009].
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Surprisingly, unlike the large age-related differences in circulating inflammatory and coagulation-fibrinolysis response seen in animal models of infection, we did not observe differences in circulating inflammatory response and showed only modest differences coagulation-fibrinolysis response between older and younger subjects hospitalized for CAP.
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