In contrast, passive stiffness was found to be increased in skinned cardiomyocytes from biopsies of patients with diastolic, but not systolic heart failure, likely a consequence of altered titin function.
Chronic obese/T2DM rats exhibited cardiac steatosis, apoptosis, fibrosis and hypertrophy, and diastolic (but not systolic) dysfunction.
In conclusion, our results demonstrate that higher BNP levels in a non heart failure range were independently associated with increased LV mass and deteriorated LV diastolic function, but not LV systolic function over time, particularly in individuals with type 2 diabetes.
Plasma MPO was weakly correlated to PR3 SERPIN andaNT-proBNPBNP (rs=0.11 and 0.12, respectively, P=0.002) but not to LV systolic function.
10 The other report is that plasma GLP-1 level was associated with diastolic heart function but not with systolic heart function in elderly men who were invited to a healthy survey.
Elevated plasma FA concentrations, induced by exercise in the fasted state, lead to increased cardiac lipid content, but do not acutely hamper systolic function.
In summary, in this study, we revealed that elevated plasma FA concentrations, induced by prolonged exercise in the fasted state, increased storage of triglycerides in cardiac tissue, but did not acutely hamper systolic function.
Endothelium derived NO has been shown to have positive effects not only on diastolic, but also on systolic function [ 18].
However, verapamil/diltiazem treatment did not affect cardiac systolic function as shown by similar LVEF between NDHP and control group.
However, verapamil/diltiazem treatment did not affect cardiac systolic function as shown by similar LVEF between verapamil/diltiazem and control group based on data from this analysis.
