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Other anti-apoptotic Bcl-2 family members were expressed but not substantively altered at the mRNA level in the Bcl-x-null tumors, suggestive of redundancy without compensatory transcriptional up-regulation.
The HR of 1.422 955% CI 1.149 to 1.758; p=0.001) is slightly larger compared to the primary analysis but not substantively different (table 4).
For example, persistent patients were statistically but not substantively younger than non-persistent patients (measure 1: 58.6 versus 60.7, p < 0.0001; measure 2: 59.7 versus 60.8 years, p = 0.0043).
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The equity in health outcomes could hardly be improved if the traditional free medical service system for cadres was only nominally integrated into BMIE but did not substantively decrease the relative disparities in medical benefits.
This mixing will be dealt with in detail elsewhere, but does not substantively change the broad picture presented.
Both UNICEF and USAID staff advised the study team, but did not substantively affect the study design, instruments or interpretation of data.
Typical of level 1, this question is situated in a phenomenological context that appears biological (it involves a protein), but does not substantively engage with biological ideas.
Current oral AHA classes often do not provide sufficiently effective or durable glycaemic control with improved βCF; although metformin provides modest weight reduction, most oral agents lead to weight gain or are weight neutral, but do not substantively reduce body weight [ 1, 5].
These limitations may impose a modest constraint on the interpretation of these findings, but they should not substantively undermine the internal validity of the study.
We dichotomised our outcome measures for ease of interpretation, but the results were not substantively different when the full range of outcome responses for SRH and QoL was explored.
We also restricted the peak exposure period by specifying models with the wildfire duration defined as 2 weeks or 1 week of peak intensity instead of 3 weeks to assess sensitivity to the duration of the wildfire event, but main effects were not substantively altered (data not shown).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com