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Central but not peripheral administration of the selective CCK-B receptor agonist, pentagastrin, produced an anxiogenic-like action [ 114].
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We found that acute administration of Cbl was effective in reducing mechanical allodynia but not peripheral inflammation in the CFA model of inflammatory pain.
Furthermore, the direct administration of the DPP-4 inhibitor into the rat portal vein significantly increased portal (but not peripheral) GLP-1 and insulin levels and decreased glucose concentrations (14).
Leptin also exerts peripheral effects on BAT since peripheral, but not central, administration of leptin in rats increases the insulin-stimulated utilization of glucose in BAT.
Leptin administered peripherally in animal models such as rodents promotes weight loss and satiation, but peripheral administration of leptin in obese human does not promote significant weight loss [ 32, 41].
However, because solution 3 requires CO2-impermeable storage, solution 2 might be preferable, provided its higher pH does not preclude rapid peripheral administration.
Moreover, basal S6 activity was also detected in larger motor neurons in the ventral horn, but it was not modified by carrageenan peripheral administration [ 54].
NMO-like lesion could not be reproduced by peripheral administration of only NMO-IgG, even in immature rodents with a leaky blood brain barrier (BBB) or in BBB-permeabilized adult rodents [ 20].
Etanercept does not cross the BBB after peripheral administration, because of its high molecular weight (51 kDa).
"But not the administration and the Regents".
These authors described an increase of cGMP levels in liver veins of cirrhotics after oral administration of 50 mg sildenafil but not in peripheral veins leading to a significant decrease of sinusoidal resistance but not of peripheral vascular resistance.
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