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Ab2/3H6 Fab binds to 2F5 Fab′ via a helix-like protrusion formed by residues 58(H)RYSPSLNTRL67(H) of the 2F5 Fab′ variable domain and proximal to but not overlapping with the gp41 664DKW666 epitope-binding pocket.
The team found AMY-binding plaques in all 32 Alzheimer's brains they examined; the plaques usually were near to, but not overlapping with, the senile plaques.
The inhibitor-binding pocket is proximal to, but not overlapping with the NTP binding site (Figures 8A).
The IκB_ank binding site is close to, but not overlapping with, the AKT_PH binding surface on TCL1A [5], corroborating that TCL1A can bind IκB and AKT simultaneously.
In contrast, co-staining with the pre-synaptic marker synaptophysin revealed that hCAR staining was often closely opposed to, but not overlapping with, synaptophysin-positive puncta (Figure S1 I L).
Co-staining for CENP-A, a centromere-specific protein, demonstrated that signals visualized with anti-Dicer antibodies were close to but not overlapping with the pairs of CENP-A-specific signals, consistent with the Dicer localization on p-arms of acrocentric chromosomes (Fig. 1A).
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If a CGI contained at least one bp of a known gene, but not overlapped with its 5' or 3' region, it was considered as an intragenic CGI.
If a CGI contained at least one bp of a 3' region of any gene, but not overlapped with its 5' region, it was considered as a 3' CGI.
One further miRNA, mir-1388, is identified by low confident BLAST and by deepBlockAlign, but is not overlapping with an RNAz loci (Additional file 1: Figure S6).
As can be seen in Figure 5A, DSEs in poly(A) sites that constitute an A-rich upstream sequence (defined as a hexamer with ⩾5 adenosines but excluding AAUAAA and not overlapping with A(A/U UAAA) have a significantly higher frequency of uridines in the +1 to +40 region compared with A(A/U UAAA poly(A) sites.
not overlapping with zero and that had >30 per mil enrichment were considered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com