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These drugs are effective as monotherapy for hematologic malignancy [ 44, 45], but not in solid cancer.
The characteristic asexual biflagellate zoospores, important for the diagnosis, can be induced in liquid media but not in solid cultures.
However, the clinical efficacy of toxins has mainly been observed in hematological malignancies, but not in solid tumors, including GBM.
Bcl-2 was found to be prominently expressed in leukemia/lymphoma lines but not in solid tumor cell lines.
It was also detected at low incidence in other MPNs, but not in solid cancers (Scott et al., 2005; Steensma et al., 2005).
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In common with many fluorophores, DAPP exhibits a high fluorescence quantum yield30,31 in solution (Φ=53%) but not in the solid state (Φ=0%) as a result of aggregation-induced quenching.
When you make a granita, you freeze the blended fruit mixture in a pan, scraping it with a fork at 30-minute intervals as ice crystals begin to develop around the edges, until it is all frozen but not in a solid block.
Alemtuzumab stimulated low but significant levels of IFNγ release (P = 0.0020 and P = 0.0007 at 24 and 72 h, respectively) in the aqueous phase assay, but not in the solid phase assay (Table 2).
However, in contrast to most other anti-vascular agents (Rustin et al, 2003), bevacizumab has shown single-agent activity in ovarian cancer (Burger et al, 2007; Cannistra et al, 2007), but not in many other solid tumour types (Cobleigh et al, 2003; Sandler et al, 2006; Giantonio et al, 2007).
But not only in solid tumors, also in hematologic neoplasias, fractal characteristics showed to be important prognostic factors.
In addition, loci tested in these studies are known to be unstable in solid but not in haematological malignancies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com