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EphA2 expression was found in both highly aggressive uveal and cutaneous melanoma cells, but not in poorly aggressive melanoma cells.
In particular, high calcium concentration induced involucrin mRNA and protein in keratinocytes but not in poorly differentiated SCC4 cells (Gibson et al, 1996).
While this does not appear to be consistent with oxygen regulation, it matches in vitro data where involucrin is induced by hypoxia in moderately differentiated SCC9 cells but not in poorly differentiated SCC4 cells.
In summary, we have shown in this study that 2-DG is very effective in depleting intracellular ATP and inhibiting proliferation in highly glycolytic cells but not in poorly glycolytic cells.
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The addition of verapamil resulted in the increase of intracellular Hoechst 33342 in the well differentiated HepG2 and HuH-7 cells but not in the poorly differentiated cells (JHH-6).
It is concluded that cysteine proteinases play a transient role at the start of tumour development only when cancer cells are surrounded by stroma as was the case in the moderately differentiated but not in the poorly differentiated pancreatic tumours.
A potential implication of this protein in rhizobial competitiveness might exist, since it is up-regulated in response to the flavonoid daidzein in B. japonicum strain 4534, a strain highly competitive for nodulation, but not in the poorly competitive B. japonicum strain 4222 [ 105]; it is noteworthy that CPAC 7 is also competitive.
DCBLD2/ESDN expression was analyzed in our (unpublished data) and other laboratories [ 63, 65] in melanoma and breast cell lines and found to be expressed only in highly metastatic cells but not in their related poorly malignant variants suggesting a positive role for DCBLD2/ESDN in tumor progression.
Immunohistochemistry for ANXA1 revealed high expression level of this protein in well-differentiated squamous cell carcinomas, but weak or not in poorly differentiated carcinomas (Additional file 1: Figure S1).
"Media has to be more critical of stories that relate to Hispanics and not traffic in poorly vetted stories and misinformation," Miguel Ferrer, a senior adviser to Media Matters, told The Huffington Post.
The issues at hand deserve attention, but not in a play so poorly conceived and dishonorably discharged.
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