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The reduced JNK dose results in defective c-Jun NH2-terminal phosphorylation in thymocytes but not in peripheral T cells, in which nuclear factors of activated T cells (NK-ATs -DNA biNK-ATs -DNAity is affected.
Indeed, for Patients 2 and 3, we could detect small cell populations bearing mutations associated with the resistant subclone within the pre-treatment cells, but not in peripheral blood mononuclear cell (PBMC) from normal adult donors (Fig. 3d).
Trauma produced changes in tissue T-cell phenotypes but not in peripheral blood T-cell phenotypes.
A substantial increase of CGRP levels in jugular vein but not in peripheral vein in migraine attack [43].
Migraine attacks and trigeminovascular activation have also been reported to cause a CGRP increase in internal [13] and external jugular blood [3], but not in peripheral blood, which could suggest a localized activity in cranial vascular afferent pathways [3].
Although we could reproduce the finding that pain facilitation is present in subjects with tension-type headache also for migraine subjects, this facilitation was only found in trigeminal pain perception but not in peripheral [19].
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Detecting maspin mRNA amplification by RT-PCR, several authors, as mentioned above, showed maspin in normal breast epithelial cells and in primary and metastatic breast cells, but not in the peripheral blood of healthy donors.
Migraine subjects showed a significantly higher pain rating after suprathreshold stimulation in the trigeminal region as compared to healthy subjects (4.8 ± 1.6 versus 3.8 ± 2.2, p < 0.04 after Bonferroni correction) but not in the peripheral region.
The resulting knockout mice were devoid of BMAL1 expression in the forebrain/SCN but not in other peripheral tissues.
Third, the mutation is heteroplasmic and present in the affected skeletal muscles but not in the peripheral blood lymphocytes.
These results suggest that modulation of IGF1R signaling in nervous tissue, but not in the peripheral tissues, is an important factor in the evolution of longevity in mammals.
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