Genes in the islet tumor cluster were generally expressed at high levels in the isolated islet cells but not in isolated pancreatic duct cells (Figure 2).
In keeping with this proposal, our data permit to explain the observation of a defective mitochondrial respiration found in muscle strips but not in isolated mitochondria from PGC-1β KO mice under basal conditions [20].
Wt α-Syn, however, only induced the release of MCP-1/CCL2 and MIP-1α/CCL3, but not in isolated microglia, suggesting potential differential effects of Wt α-Syn and its variants on Th1/Th2 activation and/or recruitment, and a more prominent effect for A30P and E46K α-Syn variants in adaptive immune responses in PD.
Overall, LPS resulted in significantly different force-frequency dependence in cardiomyocytes, but not in isolated hearts or in vivo.
PLIN5 overexpression augmented fat oxidation in muscle homogenates containing both LDs and mitochondria but not in isolated mitochondria.
Additionally, PCR results showed that PI-1 was in ST1339 isolates but not in isolates of the single locus variant ST2268.
Such pathways, we rationalized, would only be required in the context of intact cells, but not in isolated mitochondria, where FFA alone are strong activators of Ucp1.
Instead, these two isolates contained a complete copy of the phage ST64B, which is also identified in many previously sequenced Salmonella isolates but not in isolates in clade A, B, LT2 and the Japanese isolate T000240 [ 9].
The PVL genes have been detected in approximately 50% of S. aureus isolates that are responsible for subcutaneous abscesses and cellulitis, but not in isolates that are associated with deep-seated infections [ 36].
In addition, miR-216a expression was already demonstrated to be detectable in human endothelial cells but not in isolated mouse cardiac myocytes and fibroblasts suggesting that it might take part in the physiological and pathophysiological vascular processes.
