Here too, according to the current French Legislation, this did not need the opinion of a research ethics board.A normal distribution fitted fairly the distribution of the logarithms of Cyfra values in non-diseased subjects but not in diseased subjects.
In recent years, the community has also started to focus on differential coexpression analyses (Choi et al., 2005; Kostka and Spang, 2004; Watson, 2006), which aim to identify sets of genes that are always coexpressed in non-diseased individuals but not in diseased individuals or vice versa.
The known enhancing effects of estradiol on synaptic plasticity and memory in the normal brain (reviewed in [ 151- 153]), juxtaposed to its conflicting effects on cognition in the diseased brain, lead us to an intriguing hypothesis we wish to put forth: Estrogens benefit cognition in the normal, aging brain but not in the diseased, AD brain (or in the brain at risk for AD).
Previous studies of grapevine have suggested that recovery from phytoplasma disease is associated with down-regulation of enzymatic H2O2 scavengers, supported by direct evidence of the accumulation of H2O2 in the leaves of recovered plants but not in healthy or diseased plants [ 15].
Patients with eGFR levels < 60, 60-89, or > 90 ml/min/1.73 m2 differed in age, the presence of hypertension, smoking status, serum triglycerides levels, uric acid levels, fasting glucose levels, hemoglobinA1c, the homeostasis model assessment ratio (HOMA-R), and serum A-FABP levels but not in the number of diseased vessels or the stenosis score.
Instead of trying to understand disease mechanisms, some companies are using new technology called proteomics to screen cells or blood rapidly, looking for proteins present in diseased people but not in healthy ones.
Notably, four out of seven (57%) of the 10 total variants identified using D iamund were validated by Sanger sequencing and thus were confirmed as being present in diseased cells but not in the normal cells.
The consistent dysregulation of the RNA splicing factor SRRM2 in two different PD neuronal sources and in PD blood but not in blood of other neurologically diseased patients makes SRRM2 a strong candidate gene for PD and draws attention to the role of RNA splicing in the disease.
Moreover, some factors of the anti-oxidant system (superoxide dismutase, catalase, glutathione peroxidase) were correlated in the diseased but not in the control miners.
Four of the five variants identified by D iamund were validated by Sanger sequencing as being present in the diseased but not in the normal fibroblast DNA.
However, a search for genes specifically up-regulated only in diseased Nd-1, but not in wilting Col-5 plants, led to the identification of 172 genes whose expression was also altered in wilting Col-5 plants albeit to a lower extent, and were therefore not originally selected due to our stringent selection criteria (Figure S1B).
