As no PKCδ-selective inhibitors had been developed to date, we initially used pharmacophore modeling and docking of rottlerin, a well-established but not highly-specific inhibitor of PKCδ, into the crystal structure of PKCθ, to identify regions of the molecule important for PKCδ-selectivity.
Elevated blood lactate levels are likely a result of respiratory chain dysfunction but are not highly specific.
These results suggest that the putative receptor recognizes key features of the glyceryl headgroup but is not highly specific for the substituents on the prostanoid ring.
But the PSA test is not highly specific to prostate cancer, and it's not very helpful at indicating whether a tumor is likely to become metastatic and spread to other organs.
However, extending the findings of Daley et al. [11], we have demonstrated that mAb RB6-8C5 is not highly specific for neutrophils but binds a range of additional leukocyte populations in the lung of influenza virus-infected mice, including CD8+ T cells, macrophages, NK cells and conventional and plasmacytoid dendritic cells (cDC and pDC, respectively).
Assemblages were not highly specific to single habitats, but diverged significantly between treatments in abundance and species dominance.
However, similar to other innate immune effectors, the bactericidal activity of galectin-4 is not highly specific for the blood group B antigen, but also for α-1, 3-galactose, which is another surface carbohydrate that expressed by E. coli (Liu and Bevins, 2010).
There are definitive signs of impending rupture (an aneurysm size increase especially with a rapid enlargement rate, focal wall discontinuity, hyper-attenuating crescent sign, thrombus fissuration, draped aorta sign or periaortic stranding); unfortunately these signs are often not highly specific [29, 30] (Fig. 8) but detection of these findings advocates urgent treatment.
A prospective multicentre study using the cytotoxicity assay as a gold standard revealed a PPV value of 50.9% and a specificity of 94.3%, indicating that this assay is not highly specific when used for broader testing [ 14].
