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We also identified other genomic regions with this compositional bias (but no detectable sequence similarity) that might be functionally similar.
The sequenced part of the mitochondrial genome of E. crassus contains 10 genes of the electron transport chain, 6 ribosomal protein coding genes, 2 ribosomal RNA genes, 5 transfer RNA genes, the ccmF/ jeyR gene and 11 orfs with significant sequence similarity to E. minuta genes, but no detectable sequence similarity to other known genes (Table 1, 2).
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Accordingly, NISE were identified as pairs of enzymes that had been assigned the same EC number but showed no detectable sequence similarity to each other.
Their work should be very sensitive at detecting homologs, while our novel MBOMP predictor has the potential to detect analogs or distant homologs with no detectable sequence signal remaining.
Consistent with previous reports, JAZ has very low affinity for duplex DNA or single-stranded RNA, but it binds preferentially to double-stranded RNA (dsRNA) with no detectable sequence specificity.
Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1.
Thus, two proteins that share no detectable sequence similarity can be discovered by structural techniques to have the same fold, and are most likely homologous.
The extent of sequence diversity within each infection sample compared to the local population diversity was assessed using the FWS fixation index, which has a potential range from zero (where an infection contains as much diversity as the total seen across the local population) to 1.0 (an infection containing no detectable sequence heterogeneity).
We then describe how we have used structure-based modeling to show that several other viruses with no detectable sequence similarity are likely to have coats constructed from similar proteins the "double-barrel trimer".
Nowadays, advances in bioinformatics provide a powerful tool for elucidating the functional features of genes or their promoters, and also prediction tools to identify specific elements within promoters sequence directly with no detectable sequence similarity [32].
However, across RTKs, the JM segment displays little or no detectable sequence similarity.
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