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In the QTL mapping, the detected QTL was fixed as the genetic background for next round QTL identification but no conditional analysis was performed in the present GWAS.
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Indeed, this is just what the new dispositionalists have attempted to achieve (see section 5.1), and there is no reason that Bok could not draw upon their proposal, one that embraces a dispositionalist account of regulative control, but shuns a conditional analysis of dispositions.
First, we ran the conditional analysis by conditioning on the previously reported European SNP.
Second, we also ran the conditional analysis by conditioning on the top SNP in our sample.
Conditional analysis indicated no associations independent of rs12504282 (all p>0.1).
There are no non-synonymous SNPs in the region that pass the genome-wide significance threshold, and conditional analysis revealed no secondary signals.
While TreeScan performs a second round of testing for significant partitions conditional on partitions identified in the first round of analysis, no additional significant partitions were identified upon conditional analysis in this dataset.
x|y2b: Indicates that trait x is conditioned by trait y using the second conditional analysis method.
Moreover, no significant association was found on GGA1 after conditional analysis of the results of the bivariate GWAS, and the genomic control inflation factor was reduced to 1.06.
Subsequent conditional analysis on this SNP indicated no other independent associations and suggested the presence of a single, common risk haplotype in this locus (Supplementary Material, Fig. S1).
Conditional analysis of this highly associated variant revealed no other signals of association, indicating a single-associated haplotype in this locus.
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