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Accordingly, the pre-cleaved version EpICD was not dependent on cell-to-cell contact in order to induce c-myc and cell proliferation, but necessitated nuclear translocation.
The Distributed Annotation System (Jenkinson et al., 2008) is an attempt to design a generic REST system for a biological 'data, but necessitated custom client libraries coupled with an XML format seen as verbose and inflexible.
Stepwise strategies using an HbA1c cut-off point of 37 48 mmol/mol (5.5 6.4%) could prevent twice as many cases of diabetes, compared with strategies using an HbA1c cut-off point of 42 48 mmol/mol (6.0 6.4%), but necessitated offering interventions to three to five times as many people (more than twice as many people needed to undergo treatment to prevent one new case of diabetes).
Spooling backwards to March 2003, and the eve of the invasion of Iraq, when Blair told the house that Saddam Hussein's weapons on mass destruction not only justified invasion but necessitated it as an urgent act of self-preservation, 412 MPs voted for the war, 149 against.
Corneal edema could be medically managed in one eye but necessitated a repeat surgical intervention in the other eye for removal of the Ozurdex® implant.
However, this did not affect the design directly, but necessitated more public information in the project sites.
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But inbreeding necessitated by its small numbers has forced the Jamaican iguana into a genetic bottleneck, making it susceptible to dangerous mutations, parasites and disease.
Faith is thus a passionate commitment, not based upon reason but inwardly necessitated, to that which can be grasped in no other way.
Thus, if Simmias is taller than Socrates, this is to be explained by appealing to a pair of sui generis accidents that are distinct from, but nonetheless necessitated by, Simmias's and Socrates's heights.
Our objective was to investigate changes in total protein as a potential new biomarker of aging, but this necessitated first the development of a fluorescence microscopy method to detect and quantify any changes.
Leibniz holds that the will is not causally determined in the act of choice but merely "morally necessitated".
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