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The mechanisms by which TZDs exert their insulin sensitizing action in skeletal muscle of type 2 diabetic patients are not yet fully understood, but may include increased downstream insulin receptor signaling [10], [11] and enhanced fatty acid uptake and oxidation [12], [13].
The mechanism of improved haemodynamics following exercise has not been established, but may include increased shear stress with improved structural compliance, nitric oxide related vasodilation and reduced sympathetic drive [ 31].
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But those background rates have fluctuated over the past decade, for reasons that may include increased parental and societal awareness and shifting definitions of the disorder.
The GOI has begun to weigh a policy response that may include increased Afghan police and military training/assistance.
However, long-term use of corticosteroids can have harmful side effects, which may include increased blood pressure, renal damage, and osteoporosis.
For example, in regions experiencing increased frequency and severity of extreme weather events, climate-related water quality threats may include increased runoff pollution and discharges from combined sewer overflows.
Consequences of adding stations may include increased mobility, higher land values, increased employment opportunities, environmental impacts, and reduced congestion.
Physical exam findings may include increased jugular venous pressure, palpable right ventricular impulse, increased second heart sound, and an S4.
Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis have been reported in subjects with Alzheimer's disease (AD) and may include increased cerebrospinal fluid (CSF) cortisol concentrations.
It is suggested that the mechanisms mediating Type A behavior and coronary heart disease may include increased cardiovascular and neuroendocrine responses as well as unfavorable lipid profiles.
"Adjustments may include increased liquidity offerings; a more gradual approach to financial regulatory tightening; and funding for infrastructure projects," UBS economists led by Donna Kwok wrote in a research note to clients dated July 16.
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