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Despite the complex molecular etiology of SLE, corticosteroids are commonly used to treat most of the SLE patients but long term usage of these drugs may induce numerous side effects, urging a need to develop more target- or mechanism-based therapy with less adverse effect.
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Clinically, immunosuppressant is commonly applied to prevent immune rejection of transplanted organs or cells in patients, but long-term usage can render recipients vulnerable to infection, as well as susceptible to tumorigenesis (Hernandez et al., 2010).
After adjusting for cardiovascular disease and other factors, these associations were also reduced but long-term usage remained significant (AOR 1.18, 95%CI 1.05 to 1.34, P = 0.007).
The aggregation and passivation of nZVI particles decreased its efficiency during relatively long term usage.
However, using CXCR4 antagonists for a long term usage presents potential serious side effect due to their stem cell mobilizing property.
Permanent antibacterial coatings have been developed by brush-like polyethyleneimine (PEI) on polyurethane (PU) ureteral stents since bacterial adhesion and biofilm formation with the following encrustation on stent surface limit their long term usage.
Long term usage can cause skin irritation (12) and it can be absorbed through skin.
Therefore, storage tanks are commonly used to ensure that there is sufficient water for short or long term usage.
Long term usage isn't recommended, as bacteria can build up between the spaces between the grill and the actual teeth, causing bad breath and tooth decay.
E, the vitamin -- When taking fish oil supplements for dry eye, it's recommended that you also take vitamin E. Long term usage of fish oil may deplete you of vitamin E, so it's best to be on the safe side.
Effects of long term usage of the extracts such as mutagenicity and genotoxicity also need to be determined.
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