I had to identify the body the next day, and he too looked at peace, but because I wasn't present at his death it all had a less profound effect upon me.
They give Chris Ativan every day; it has a similar though less profound effect on his behavior.
"This is the only way to really bring the story to the people here," explains director Chhay Bora, 49, who lost two brothers at the hands of the regime and says that a documentary would have had a less profound effect.
Moreover, chondrosarcoma cells yield a less profound effect on the gene expression profile under hydrostatic pressure (continuous and 0.5 Hz cyclic pressure at 5 MPa) than that under cyclic stretch (8% strain at 0.5 Hz) (Karjalainen et al., 2003).
In contrast Neurod1, which is regulated by Neurog1 expression in neurons, shows a less profound effect on sensory epithelia [15], [16].
This apparent disparity between the relative effect of Gas6 and Axl deficiency upon oligodendrocyte survival in mice challenged with cuprizone suggests that a loss of signalling through a single receptor (Axl) has a less profound effect than a reduction in signalling through all three receptors, such as in the absence of the ligand Gas6.
Treatment with the uncleavable controls resulted in a much less profound effect (IC50 values of ∼40 and 30 ng/ml for the uncleavable DTA based toxin toward uninfected and infected cells, respectively, and ∼900 and 800 ng/ml for the uncleavable RTA based toxin toward uninfected and infected cells, respectively).
A similar, though less profound effect was observed at E11.5 in hearts that are hypomorphic for NKX2-5 expression.
In the current study there was a less profound effect with no significant change in the ICP following a HTS bolus.
In the same xenograft model, chemotherapy with doxorubicin, 5-fluorouracil, cisplatin, bleomycin, methotrexate or 2',2'-difluorodeoxycytidine yielded a less profound effect on tumour volume doubling time.
