Another less widely studied enzyme of folate/one-carbon metabolism, the cytosolic serine hydroxymethyltransferase (SHMT1), has a frequent but functionally less characterized Leu- > Phe polymorphism (SNP variant C1420T).
Nfil3 (Carey et al., 2013, Pletinckx et al., 2011), Med13l (Angus and Nevins, 2012), Foxo1 (Kerdiles et al., 2010, Ouyang et al., 2012), IL-24 (Myles et al., 2013), CD24 (Blair et al., 2010), and Tnfrsf9 (Eckstrum and Bany, 2011) have also been reported as immunosuppressive factors but are less characterized.
MDP2 is functionally less characterized, but homology searches suggest that it contains an Alba protein domain and therefore may be a cytoplasmic RNA binding protein [ 27].
Similarly, different forms of PCD can be observed in prokaryotes but these are in general less characterized.
LGG-2 has been much less characterized than LGG-1, but it can be used as a convenient alternative marker to monitor autophagy activity during development.
The genomic and transcriptomic landscapes of breast cancer have been extensively studied, but the proteomes of breast tumors are far less characterized.
As for somatic cells, apoptosis of damaged spermatogonia is controlled by the tumor suppressor p53, but its downstream apoptotic effector(s) remain far less characterized [1], [2].
But the breadth is continuing to improve, with projects dedicated to filling in less characterized taxonomic groups.
The less characterized cardioviral Leader is a shorter protein (67 76 amino acids) and does not contain recognizable proteolytic motifs.
Society doesn't seem to be opposed to the concept of peace; rather, it seems we have lost hope and the idea of peace is more or less characterized as intangible.
