Icotinib, which has a clinical efficacy similar to that of gefitinib but less adverse effects [ 65], is approved for the treatment of EGFR-mutant lung cancer in China.
Studies have demonstrated that lower doses of misoprostol are associated with similar levels of uterine pressure but less adverse effects, which seems to indicate that lower doses could be used with similar levels of efficacy [ 25].
Relative to MMSE, age had a less adverse effect on PAL (0.6% per 10 years) but, in order, an increasingly adverse effect on VF-cat (0.1% per 10 years), HVLT (0.1% per 10 years), DMTS (0.3% per 10 years) and VF-lex (0.3% per 10 years).
This agent has less adverse effect on metabolic parameters than other diuretics (45, 46), is more effective than enalapril in reducing left ventricular mass (47), is equivalent to enalapril in reducing microalbuminuria (48), and is effective in reducing CV morbidity and mortality in clinical trials (3, 9, 16, 49).
Notably, complex 9 effectively inhibited tumor growth in the NCI-H460 xenograft mouse model with less adverse effect than cisplatin.
Optimum levels of fiber contents for spalling protection with a less adverse effect on workability are provided based on the results of the fire test by varying the NY and PP fiber content.
Despite the complex molecular etiology of SLE, corticosteroids are commonly used to treat most of the SLE patients but long term usage of these drugs may induce numerous side effects, urging a need to develop more target- or mechanism-based therapy with less adverse effect.
Taken together, our treatment modality may provide a more beneficial treatment outcome with less adverse effect.
How to enhance the mass transfer with less adverse effect is considered as one of the important bioengineering issues.
Furthermore, abatacept has less adverse effect than infliximab, suggesting it is biologically safer and a more tolerised treatment [ 18, 19].
