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The strong increase in hexose levels observed for sink organs under drought was associated with up-regulation of several invertase genes (OsCIN 1, 5, 8 and OsVIN 1, 2; (Luquet et al. 2008) and was thus suggested to be passive, but its physiological function remained unclear.

Several studies implicate CTGF as a factor being involved in tissue remodeling after myocardial infarction, but its physiological function in ischemia and following muscle recovery remains elusive [23], [24], [31].

Furthermore, there is evidence that the absence of CB1 receptor also participates in the expression of MDMA induced hyperthermia [31], indicating that not only the pharmacological activation of this receptor, but its physiological function plays an important role in the hyperthermic effects of MDMA.

In normal tissues LNX5 mRNA expression is largely confined to the brain, but its physiological function here is unknown [ 4].

Available data indicate that this gene is expressed exclusively in the avian eye, but its physiological function remains a mystery.

Finally, recently a specific PC1 inhibitor, ProSAAS has been identified [ 10], but its physiological function remains unclear.

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Among the 12 members of the AKR1B subfamily, aldose reductase (AKR1B1 in human and AKR1B3 in mouse) has been a focus of interest because of its role in the development of secondary diabetic complications but its physiological functions remain poorly understood [2].

Butyrylcholinesterase is present at more than 10 times the level of AChE in whole blood, but its physiological functions are not completely understood.

The resultant dynamic mitochondrial network has become commonplace to cell biologists, but what is its physiological function?

Deciphering the sub-compartmental location of a given protein of interest may help explain its physiological function, but it can be challenging to do using optical or biochemical methods.

Phosphorylation of Y340 in c-Raf itself is important for association to MEK, it's most important substrate, thus auto-phosphorylation of c-Raf at this residue may contribute to its physiological function, but obviously further studies are essential for answering this question.

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