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It is frequently downregulated in cancer, including prostate cancer, but its function in prostate cancer is unclear because it can increase proliferation of prostate epithelial cells.
Rex-1 is involved in maintaining an undifferentiated state of ESCs and it is also expressed in bone marrow MSCs, but its function in the dental follicle is unclear.
Sirt1 is expressed in the kidney podocyte, but its function in the podocyte is not clear.
Interleukin-6 (IL-6) is expressed in osteoarthritic joints but its function in osteoarthritis (OA) is unknown.
QKI is also highly expressed in astrocytes, but its function in these cells is not known.
Thus the PA subunit has a crucial role in RNA replication and viral proliferation, but its function in host restriction and thermal stability are still poorly understood.
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α-Synuclein is expressed in hematopoietic and immune cells, but its functions in hematopoiesis and immune responses are unknown.
The serotonin (5-HT) pathway was shown to play a role in pulmonary hypertension (PH), but its functions in right ventricular failure (RVF) remain poorly understood.
Pan1 is categorized as a class II NPF (Welch and Mullins 2002), but its functions in regulating Arp2/3 complex are still not well understood.
TSPAN8 plays an important role in pancreas development in Xenopus embryos (Ref. 134), but its functions in mammalian development and adult physiology are not well defined, so the extent to which targeting TSPAN8 in tumours might cause undesirable side effects in normal tissues remains unknown.
Additionally, IP3R is distributed in ventricular intercalated discs, but its function(s) in this particular site remains unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com