However, its exact contribution to disease progression has been for a long time a matter of debate.
Longitudinal studies are needed to assess the variation of asymptomatic parasite carriage over time, and its exact contribution to transmission.
We conclude that this loop is important for catalysis, although its exact contribution is unknown.
In Chlamydomonas, RNAi-mediated knockdown of IFT27 causes flagellar defects (Qin et al., 2007), supporting its role during flagellar assembly, although its exact contribution was not investigated.
The IFT dynein is the retrograde motor of IFT that brings back IFT trains from the tip to the base of the flagellum, a process in which IFT-A is also involved although its exact contribution remains to be shown.
The MAP kinase pathways are known to be involved in adipogenesis but their exact contribution is still partially controversial [38].
It has been documented that endogenous cellular polyamine level is dependent upon several interconnected pathways, such as de novo synthesis, degradation and conjugation, but the exact contribution of an individual pathway is not yet identified.
Smooth muscle tone is regulated by both the parasympathetic and sympathetic nervous systems but the exact contribution of each of these systems in maintaining tone in physiology and disease is unclear in airways [ 77 ] and bladder.
It is thought that one important structure where information on eye position is stored is an area towards the back of the brain called the lateral intraparietal cortex, but the exact contribution of this region has long been controversial.
Several processes related to glucose toxicity, abnormalities in cerebral insulin homeostasis, and microvascular abnormalities have been implicated [ 41], but their exact contributions to abnormalities in cerebral function and structure in diabetes still need to be elucidated.
